Incredible diversity of climates and cultures.  So much to explore and discover,  2 Trips would be the most suitable although many do not have that luxury.  Prioritize the kind of weather and sights you want and work from that.

PHOTOGRAPHY SUGGESTIONS

Such diversity makes it hard to suggest specific places, the most well known are
Torres del Paine, Patagonia, Argentina
Atacama Desert, Chile
Amazon Brazil
Pantanal, Brazil
Iguaza Falls, Brazil & Argentina
Galapagos, Ecuador
Machu Picchu, Peru
Easter Island, Chile

Like to see more about other continents we have visited, Go to our destinations page.